hIGF1R(2)

品系全名

C57BL/6Smoc-Igf1rem(hIGF1R)Smoc

目录号

NM-HU-230053

品系状态

活体

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基因信息

基因名
Igf1r

品系描述

利用同源重组,将小鼠Igf1r 基因进行人源化修饰。

验证数据

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Fig.1 Detection of human IGF1R expression in female homozygous hIGF1R(2) knockin mice. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr. M, marker; WT, wild type; HO, Homozygous.

image.png

Fig.2 Detection of hIGF1R expression in the lung of female homozygous hIGF1R(2) knockin mice. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.3 Detection of hIGF1R expression in the brain of female homozygous hIGF1R(2) knockin mice. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.4 Detection of hIGF1R expression in the kidney of female homozygous hIGF1R(2) knockin mice. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.5 Detection of lymphcytes subsets in the spleen of female hIGF1R(2) knockin mice by FACS. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.6 Detection of myeloid cells in the spleen of female hIGF1R(2) knockin mice by FACS. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.  WT, wild type; HO, homozygous.


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