Rpe65-IRES-CreERT2
品系全名
C57BL/6Smoc-Rpe65em1(IRES-CreERT2-pA)Smoc
目录号
NM-KI-242372
品系状态
精子冻存
基因信息
基因名
Rpe65
品系描述
将IRES-CreERT2-pA插入到小鼠Rpe65基因终止密码子处。
*使用本品系发表的文献需注明: Rpe65-IRES-CreERT2 mice (Cat. NO. NM-KI-242372) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig1. CreERT2 mediated recombination in retina of Rpe65 CreERT2/+;Rosa26 tdTomato/+ mice.
Fig2. Detection of tdTomato(red) in various tissues of Rpe65 CreERT2/+;Rosa26 tdTomato/+ mice. After tamoxifen was induced, the organization of tdTomato expression: retina. Tissues that do not express tdTomato: brain, lung, kidney, reproductive system. (32-days old, female) (For more detailed information please contact our technical advisor.)
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Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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