pAlb-hLPA-3’UTR-pA-TG/hAPOB

通过pAlb-hLPA-Tg(V2)(NM-TG-231782)与hAPOB(2)(NM-HU-231781)小鼠交配获得。

 Fig.1 Detection of humanized Lp(a) complex level in the plasma of pAlb-hLPA-3’UTR-pA-TG/hAPOB dKI mice at different ages (mean±SEM).

Fig.2 Detection of (A) humanized Lp(a) complex level and (B) percentage change from baseline in the steady-state levels of Lp(a) in the serum of vehicle or Muvalaplin-treated pAlb-hLPA-3’UTR-pA-TG/hAPOB dKI mice (+/HE, n=5, mean±SEM).

Fig.3 Detection of (A) human LPA, (B) humanized APOB, and (C) relative change from baseline of hAPOB in serum from vehicle- or muvalaplin-treated pAlb-hLPA-3'UTR-pA-TG/hAPOB dKI mice (+/HE, n=5, mean ± SEM).

*Human LPA ELISA Kit : Abcam, #ab212165

Fig.4 Detection of (A) triglyceride (TG), (B) total cholesterol (T-CHO), (C) high density lipoprotein cholesterol (HDL-C) and (D) light density lipoprotein cholesterol (LDL-C) level in the blood of vehicle or Muvalaplin-treated pAlb-hLPA-3’UTR-pA-TG/hAPOB dKI mice (+/HE, n=5, mean±SEM).