Uox-Flox/Alb-Cre

品系全名

C57BL/6Smoc-Uoxem1(flox)Tg(Alb-Cre)Smoc

目录号

NM-XA-242357

品系状态

活体

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品系描述

通过Uox-Flox小鼠与Alb-Cre小鼠交配获得。

验证数据

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Fig 1. Body Weight of Uox-Flox/Alb-Cre mouse.

Abbr. WT, wild type.

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Fig 2. Uric acid (UA) levels of Uox-Flox/Alb-Cre mouse. 

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Fig 3. The results of blood biochemical indicators of Uox-Flox/Alb-Cre mouse.

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Fig 4. Histological analysis of kidney revealed no obvious micro-morphological injury in 20-week old Uox-Flox/Alb-Cre male mice.

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Fig 5. Effect of Allopurinol on Serum Uric Acid Levels. 6 week-old Uox-Flox/Alb-Cre male mice were Treated with Allopurinol. Compared to C57BL/6, serum uric acid levels of Uox-Flox/Alb-Cre male mice were significantly elevated. Treatment with allopurinol (100mg/kg) significantly reduced serum uric acid levels in Uox-Flox/Alb-Cre male mice (n=10). Values are expressed as mean ± SEM.

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Fig 6. Body Weight Comparison. The body weight of Uox-Flox/Alb-Cre male mice was lower compared to C57BL/6 mice. Allopurinol treatment had no effect on body weight (n=10). Values are expressed as mean ± SEM. 

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Fig 7. Kidney Function Assessment. Kidney function in Uox-Flox/Alb-Cre male mice showed no significant difference compared to C57BL/6 mice (n=10). Values are expressed as mean ± SEM. 

参考文献

A stable liver-specific urate oxidase gene knockout hyperuricemia mouse model finds activated hepatic de novo purine biosynthesis and urate nephropathy
来源杂志：Molecular Basis of Disease

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