Cldn18-IRES-CreERT2
品系全名
C57BL/6Smoc-Cldn18em(IRES-CreERT2)1Smoc
目录号
NM-KI-225024
品系状态
精子冻存
基因信息
基因名
Cldn18
品系描述
验证数据
Fig1. CreERT2 mediated recombination in stomach of Cldn18 CreERT2/+;Rosa26 tdTomato/+ mice
Fig2. Detection of tdTomato(red) in various tissues of Cldn18 CreERT2/+;Rosa26 tdTomato/+ mice. The organization of tdTomato expression: stomach, lung, brown fat. Tissues that do not express tdTomato: brain, spinal cord, eyeball, heart, liver, salivary glands, adrenal glands, kidneys, pancreas, large intestine, small intestine, spleen, reproductive system, muscles, skin, thymus, pituitary gland. (37-days old, male) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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