Csf1r-IRES-Cre
品系全名
C57BL/6Smoc-Csf1rem3(IRES-iCre)Smoc
目录号
NM-KI-190026
品系状态
活体
基因信息
基因名
CSF1R
品系描述
验证数据
Fig1. Flow assay of fluorescent gene expression in peripheral blood macrophages of Csf1r-Cre+/-;R26-mTmG+/- mice. In cre-expressing F4/80 macrophages, tdTomato was excised and the cells were labelled with EGFP; in F4/80 macrophages without cre expression, the cells were labelled with tdtomato and EGFP was not expressed.
Fig2. Cre mediated recombination in skin of Csf1r Cre/+;Rosa26 tdTomato/+ mice.
Fig3. Detection of tdTomato(red) in various tissues of Csf1r Cre/+;Rosa26 tdTomato/+ mice. The tissues that express tdTomato include: brain, eyeball, heart, lungs, liver, salivary glands, kidneys, small intestine, large intestine, ovaries, skin, adrenal gland, gallbladder. A small amount of expressiontdTomato are spinal cord. (7.5-weeks old, female) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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