Foxp3-IRES-tdTomato-2A-CreERT2
品系全名
C57BL/6Smoc-Foxp3em4(IRES-tdTomato-2A-CreERT2)Smoc
目录号
NM-KI-190120
品系状态
活体
基因信息
基因名
Foxp3
品系描述
验证数据
Fig1. Detection of tdTomato and zsGreen expressed on mCD4+ mFoxp3+ Treg cells in Peripheral blood and spleen in WT and Foxp3 CreERT2/+; Rosa26 zsGreen/+ mice.
Fig2. CreERT2 mediated recombination in large intestine of Foxp3 CreERT2/+;Rosa26 zsGreen/+ mice.
Fig3. Detection of zsGreen(green) and tdTomato(red) in various tissues of Foxp3 CreERT2/+;Rosa26 zsGreen/+ mice. Tissues expressing zsGeen: large intestine, small intestine, lung, stomach, spleen, pancreas, skin, thymus, mesenteric lymph nodes. Tissues expressing zsGeen in small amounts: liver, kidney. (58-days old, male) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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