Hlf-CreERT2
品系全名
C57BL/6JSmo-Hlfem1(CreERT2)Smoc
目录号
NM-KI-230441
品系状态
精子冻存
基因信息
基因名
Hlf
品系描述
验证数据
Fig1. CreERT2 mediated recombination in liver of HlfCreERT2/+; Rosa26tdTomato/+ mouse.
Fig2. Detection of tdTomato(red) in various tissues of HlfCreERT2/+; Rosa26tdTomato/+ mouse.
After tamoxifen induction, tdTomato was expressed in the brain, spinal cord, eyeballs, heart, liver, lungs, stomach, salivary glands, brown adipose tissue, adrenal glands, kidneys, pancreas, large intestine, small intestine, spleen, reproductive organs, muscle, skin, and thymus.
Tissues with expression leakage in the uninduced group: brain, eyeballs, brown adipose tissue, adrenal glands, kidneys, and muscle..(57-days old, male and female) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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