The orthotopic tumor-bearing model is one of the commonly used models for studying the pathogenesis and therapeutic approaches of glioblastoma. This model typically employs stereotaxic injection technology to implant tumor cells into the hippocampal region of the brain of rats or nude mice. This method significantly reduces surgical mortality, increases the intracranial tumor formation rate, and is stable and reliable.
Fig1. Orthotopic transplantation tumor model of U87MG-Luc glioma cells.
