hTNFR2(BALB/c)

品系全名

BALB/cAnSmoc-Tnfrsf1btm(hTNFRSF1B)Smoc

目录号

NM-HU-220499

品系状态

胚胎冻存

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基因信息

基因名
TNFRSF1B

基因曾用名

p75; TNFBR; Tnfr2; CD120b; TNF-R2; TNFR80; TNFRII; Tnfr-1; TNF-R75; TNF-R-II; TNF-alphaR2; TNFalpha-R2

NCBI ID

21938

MGI ID

1314883

Ensembl ID

ENSMUSG00000028599

Pubmed

TNFRSF1B

人类同源基因

TNFRSF1B

品系描述

利用同源重组，将小鼠Tnfrsf1b 基因进行人源化修饰。

验证数据

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Fig.1 Expression analysis of hTNFR2 on Treg cells in spleen of hTNFR2(BALB/c) humanized mice. 

Leukocytes were collected from spleen of wild-type BALB/c mice (female, 8 weeks) and homozygous hTNFR2(BALB/c) mice (male, 14 weeks) stimulated in vivo with anti-CD3ε and analyzed by flow cytometry with anti-mTNFR2 and anti-hTNFR2. hTNFR2 were exclusively detectable in hTNFR2 humanized mice but not in wild-type mice.

image.png

Fig.2 Expression analysis of hTNFR2 on DCs, monocyte, B cells, and neutrophils in spleen of hTNFR2(BALB/c) humanized mice. 

Leukocytes were collected from spleen of wild-type balb/c mice (female, 12 weeks) and homozygous hTNFR2(BALB/c) mice (male, 18 weeks), and analyzed by flow cytometry with anti-mTNFR2 and anti-hTNFR2. hTNFR2 were exclusively detectable in hTNFR2 humanized mice but not in wild-type mice.

image.png

Fig.3 Expression analysis of hTNFR2 on monocyte, B cells, and neutrophils in blood of hTNFR2(BALB/c) humanized mice. 

Leukocytes were collected from blood of wild-type balb/c mice (female, 12 weeks) and homozygous hTNFR2(BALB/c) mice (male, 18 weeks), and analyzed by flow cytometry with anti-mTNFR2 and anti-hTNFR2. hTNFR2 were exclusively detectable in hTNFR2 humanized mice but not in wild-type mice.

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