hCD3EDG/hEpCAM

Table.1 Blood routine examination in male hCD3EDG/hEpCAM mice.

Table.2 Blood routine examination in female hCD3EDG/hEpCAM mice.

Fig.1 Detection of lymphcytes population in the (A) peripheral blood and (B) spleen of 8-week-old male and female homozygous hCD3EDG/hEpCAM dKI mice by FACS (n=3). 

Fig.2 Pathological analysis of 8-week-old female hCD3EDG/hEpCAM dKI mice by H＆E staining. 

There were no obvious pathological changes in these tissues.

Fig.3 Pathological analysis of 8-week-old male hCD3EDG/hEpCAM dKI mice by H＆E staining. 

There were no obvious pathological changes in these tissues.

Fig.4 Detection of mouse EpCAM expression in 8-week-old wild-type mice (WT) by IHC with an anti-mouse EpCAM antibody. 

The arrows indicate the positive mouse EpCAM staining (brown) in each tissue. (40x Magnification) 

Fig.5 Detection of human EpCAM expression in 8-week-old wild-type mice (WT) and homozygous hCD3EDG/hEpCAM knockin mice by IHC with an anti-human EpCAM antibody. 

The arrows indicate the positive EpCAM staining (brown) in each tissue. The results show that human EpCAM is highly expressed in the intestine and kidney of hCD3EDG/hEpCAM knockin mice. (40x Magnification)