2210010C04Rik-D23A

品系全名

C57BL/6JSmo-2210010C04Rikem1D23ASmoc

目录号

NM-KI-232248

品系状态

精子冻存

导出PDF

品系描述

该小鼠携带2210010C04Rik-D23A突变。

验证数据

image.png

Fig 1. The pancreas of a heterozygous female mouse with RikD23A/+ mutation. 

Pancreatic tissue from 2-week-old and 23-week-old RikD23A/+ heterozygous female mice exhibited a loss of acinar cells, accompanied by infiltration of inflammatory cells, acinar-ductal metaplasia, fat infiltration, and fibrotic changes.The scale bar corresponds to 200 µm.


image.png

Pathology scores:0 represents within the normal range, 1 represents mild, 2 represents moderate, and 3 represents marked

图片1.png

Fig 2. The pancreas of a heterozygous male mouse with RikD23A/+ mutation

Pancreatic tissue from 4-week-old and 8-week-old RikD23A/+ heterozygous male mice exhibited a loss of acinar cells, accompanied by infiltration of inflammatory cells, acinar-ductal metaplasia, fat infiltration, and fibrotic changes；The degree of fat infiltration and fibrosis is not significant in 2-week-old mice, and other phenotypes are mild.The scale bar corresponds to 200 µm.

image.png

Pathology scores:0 represents within the normal range, 1 represents mild, 2 represents moderate, and 3 represents marked


你也可能感兴趣

Tamoxifen诱导Cre-ERT2小鼠 使用指南

Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。

查看

【小鼠大学问】基因工程小鼠的命名规则

常见的基因工程小鼠可以分为两种命名方式，包括基因定点修饰的小鼠命名，比如：敲除、敲入、点突变等等，和随机转基因的小鼠命名。

查看

Cre-lox系统介绍及使用汇总

你一定听说过Cre-lox重组系统，无论你是否直接进行过基因操作。由于Cre-lox系统具有操作简单、重组率高的优点，如今已经成为体内外遗传操作的强有力工具。利用Cre-lox系统，可以在特定细胞、组织或整个生物体，甚至在特定时间点敲除或表达某个基因，实现对特定基因的时空特异性操作，这对基因功能的研究和人类疾病动物模型的建立都具有深刻影响。

查看